Rob Lowe Rejected The Lead Role On Grey’s Anatomy


Instead of accepting the lead role in the hit series Grey’s Anatomy, actor Rob Lowe turned it down for a role in the short-lived drama Dr. Vegas.

In 2003, he rejected the acclaimed White House drama for starring in one of his own, The Lyon’s Den, which only lasted for six episodes.

In 2004, he had another opportunity to return to TV but was indecisive because both offers were medical roles.

In his new memoir “Love Life” he remembers, “I got an urgent call from the producers of a potential new show for (U.S. network) ABC called Grey’s Anatomy. I agreed to meet with the people making Grey’s Anatomy.”

“I had read it and loved it. The writing was crisp, real and very entertaining, and it’s always been a good idea to hear out talented people.”

He adds, “‘We would be thrilled if you would play Dr. Derek Shepherd,’ they said right off the bat. I was torn. Grey’s was a much better script; in fact, there was no comparison… (but) I chose Dr. Vegas. The odds were just too stacked.”

The role of Dr. Derek Shepherd went to Patrick Dempsey, who became celebrated as a household name overnight. He’s still on the show, which is currently in its 10th season.

Dr. Vegas, which starred Amy Adams and Tom Sizemore, on the other hand, was cancelled after mere five episodes.

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